![]() d) Represents Western blot detection of β-dystroglycan (β-DG) in C57BL/10 and mdx nerve extracts. c) C-ter utrophin antibody (K7) detection showed the full utrophin (Up395) in C57BL/10 and both Up395 and the short product Up71 (71 kDa) in mdx extract. b) Dp116 detection on the same extracts with C-terminal dystrophin antibody (H4). a) Western blots revealed a dystrophin isoform (Dp116) and utrophin isoforms (Up395 and Up71) in C57BL/10 and mdx total nerve extracts, using a monoclonal antibody recognizing both dystrophin and utrophin (5A3). ( A) Immunodetection of DAP complex in C57BL/10 and mdx peripheral nerve extracts. We proposed that these two proteins could be implicated in Schwann cell proliferation in response to a microenvironment stress such as mediated by accumulating macrophages in mdx mouse muscle inflammation sites. Our results highlight the potential participation of the short utrophin isoform and the cleaved form of beta-dystroglycan in mdx Schwann cell membrane architecture. In addition, this utrophin isoform (Up71) seems to have greater affinity to the 30 kDa beta-dystroglycan which could explain the increased stabilization of this 30 kDa form at the membrane compartment. Moreover, we showed for the first time that the short isoform of utrophin (Up71) was over-expressed in mdx Schwann cells compared with wild-type. Our results showed that Dp116 had greater affinity to the full length form of beta-dystroglycan than the 30 kDa form. This activation leads to an accumulation of the 30 kDa beta-dystroglycan isoform and has an impact on the anchorage of Dp116 and utrophin isoforms in mdx Schwann cells membrane. We showed that metalloproteinase-9 was more activated in mdx nerve than in wild-type ones. Here we asked if the processing of the beta-dystroglycan could influence the anchorage of Dp116 and/or utrophin in normal and mdx Schwann cell membrane. Metalloproteinase creates a 30 kDa fragment of beta-dystroglycan, leading to a disruption of the link between the extracellular matrix and the cell membrane. In peripheral nerve, matrix metalloproteinase activity disrupts the dystroglycan complex by cleaving the extracellular domain of beta-dystroglycan. sarcoglycans, and alpha- and beta-dystroglycan, which anchor the cytoplasmic protein subcomplex to the extracellular basal lamina. Dp116 is associated with multiple glycoproteins, i.e. NOTE: All combinations may not be valid, check spec sheet for valid part numbers.In the peripheral nervous system, utrophin and the short dystrophin isoform (Dp116) are co-localized at the outermost layer of the myelin sheath of nerve fibers together with the dystroglycan complex. GR-9/26 for Green Display 9/26 VDC Power GR-230 for Green Display & 230 VAC Power ![]() Nothing(leave field blank) for Standard Unit Std Unit (115 Vac), 1☌ Resolution, Type J, -210 to 760☌ Range Other people have bought when they purchased this model. What Other People Bought: When you see this icon, click on it to expand a list of products that View Panel Punches available for this product. Use the "Part Number Builder" below to get pricing for all available models. Panel Cutout: 364 DIN, 22.2 x 68 mm (0.87 x 2.68") 18 DIN adaptor (DP116-PB1) supplied with each unitĮxamples of pricing for popular models is referenced in the "To Order" box. Power: 115 Vac, ☑5%, 50/60 Hz (Optional 230 Vac or non-isolated 9/26 Vdc - no charge) Refer to the Related Links Section below.Īccuracy, Thermocouple: 1.0° models: ☒.7☏ (☑.5☌) + 1 count 0.1° models ☑.8☏ (☑☌) + 1 countĪccuracy, RTD: 0.1° models: ☐.5☏ (☐.3☌) + 0.2% rdg 1.0° models: +0.2☏ (☐.1☌) +0.2% rdg ☒.7☏ (☑.5☌) max errorĪnalog Output: non-isolated, 1 mV per degree for 1° models, 10 mV per degree for 0.1° modelsĭisplay: 3 12 digit Red LED, 0.56" (14.2 mm) digits (optional Green LED - no charge) 3/64 DIN DPF50 series is also available for process measurement. Accessories such as Bumper Band protective guards and splash-proof covers can be used for applications in harsher environments. ![]() A 3/64 DIN to 1/8 DIN panel adaptor is included with every unit. A digital copy of the manual is offered below for you to preview. In addition to the standard 115 Vac power, 230 Vac or 9 to 26 Vdc are also available. The DP116 series is a economical 3/64 DIN panel meter that has a full size 0.56" green or red LED display, built-in analog output and display hold capability. Please see the DPPT as a possible alternative or contact our Electronics Engineering department. ![]() Safety-Rated, Removable Screw-Clamp Cable Connector Temperature Panel Meter, Low Cost - Omega 3 1/2 Digit Mini-size Temperature Panel Meter - Discontinued
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